Ecm16 protein confers resistance against the DNA intercalator antibiotic echinomycin
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چکیده
منابع مشابه
World alliance against antibiotic resistance: The WAAAR declaration against antibiotic resistance.
We must change how antibiotics are used and adopt proactive strategies, similar to those used to save endangered species. Preservation of the efficacy of antibiotics and to stabilization of antibiotic-susceptible bacterial ecosystems should be global goals.
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Antibiotic resistance (ABR) is a very serious public health issue. Antibiotics have been “miracle” drugs during many years, but their activity has been reduced sharply by many mechanisms of resistance. New mechanisms make the strains of Gram‐negative bacteria resistant to the 3rd generation cephalosporins, and carbapenems. It is very urgent to act to slow down this phenomenon by global and inte...
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Production of reactive nitrogen species (NO) is a key step in the immune response following infections. NO induces lesions to bacterial DNA, thus limiting bacterial growth within hosts. Using two pathogenic bacteria, Bacillus cereus and Shigella flexneri, we show that the DNA-repair protein Mfd (Mutation-Frequency-Decline) is required for bacterial resistance to the host-NO-response. In both sp...
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Phosphoglycerate mutase family member 5 (PGAM5) is a mitochondrial protein phosphatase that has been reported to be involved in various stress responses from mitochondrial quality control to cell death. However, its roles in vivo are largely unknown. Here, we show that Pgam5-deficient mice are resistant to several metabolic insults. Under cold stress combined with fasting, Pgam5-deficient mice ...
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Phages on the surface of an Escherichia coli cell inject genetic material into the bacterium.
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ژورنال
عنوان ژورنال: The FASEB Journal
سال: 2021
ISSN: 0892-6638,1530-6860
DOI: 10.1096/fasebj.2021.35.s1.03214